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This means that while GI side effects are common on semaglutide, nearly half of placebo participants also reported them, which tells us that some of the reported symptoms are related to dietary changes and study participation rather than the medication itself

Fatigue: A temporary feeling of tiredness or sluggishness can occur as the body adjusts

Some research suggests that chronic high-dose L-carnitine supplementation may increase TMAO levels via gut bacteria metabolism, and elevated TMAO has been associated with increased cardiovascular risk in observational studies

"Sustainable treatment will likely require combination approaches, longer-term strategies, and therapies that reshape how the brain interprets energy balance, not just how much people eat," he said.