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The disulfide bridge between Cys3-Cys8 maintains the essential tertiary structure required for receptor activation

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We next assessed the production of other components of the coagulation machinery, including AT, which is one of the most potent anticoagulant proteins that inhibits multiple coagulation serine proteases, mainly thrombin (FIIa) and activated factor X (FXa) but also FVIIa, FIXa, FXIa and FXIIa