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As illustrated in Figure 5 , a significant increase in Fat-Free Mass Index was observed as early as T3 compared with T0, and the increase, although no longer significant, was confirmed until the end of the follow-up

For instance, macrophage-engineered exosomes loaded with GLP-1-encoding mRNAs promoted endogenous peptide production and glycemic normalization in diabetic models with minimal systemic immune activation [117]