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These secondary targets are not interchangeable

Conventional drugs like metformin primarily exert their effects by improving IR, and studies have shown that they can modulate the gut microbiota, albeit with no significant impact on the levels of gut microbial metabolites (108)

A 5 to 8 minute plasma half-life means that by the time subcutaneously injected DSIP is absorbed from the injection site, cleared through lymphatics into venous blood, and circulated, a very substantial fraction has already been enzymatically degraded

With a proven safety profile established through phase II clinical trials in Parkinsons and liver disease [260, 261], MitoQ supplementation effectively rejuvenates vascular EC function in aged mice by restoring mitochondrial superoxide balance and enhancing NO bioavailability [262], a finding that was subsequently validated in a rigorous randomized, placebo-controlled, double-blind clinical trial involving healthy older adults [263]