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The costumes often took weeks upon weeks to design, including hours of fittings with the actress, who often had to slip on corsets for the elaborate looks

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From a clinical point of view, the increased hepatic metabolism and the consequent reduction in plasma concentrations may lead to a decrease in the therapeutic effect of the drug, as evidenced in patients treated with olanzapine, where smokers showed a more modest reduction in psychiatric symptoms after 15 days of treatment [36]

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