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GLP-1 is secreted physiologically by enteroendocrine L-cells of the small and large intestine, and GIP is secreted by duodenojejunal K-cells in response to food intake [23]

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Poor diet, lack of sleep, and modern lifestyle further trigger this imbalance, resulting in: Collagen breakdown, driven by enzymes called matrix metalloproteinases (MMPs) Impairment in skin barrier function causes dryness, reduced hydration, and skin sensitivity Increased inflammatory signals like interleukin-1 (IL-1), triggering skin aging This ultimately leads to visible skin changes, including dullness, fine lines, and uneven pigmentation

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