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Here are long-term effects nicotine has on the body: The brain: Nicotine can alter the brain's chemistry, which may contribute to an increased risk of developing certain mental health conditions, such as major depressive disorder and bipolar disorder

A 2015 survey cited by The Truth Initiative (an anti-tobacco organisation) found that almost 60% of those who used e-cigarettes also smoked cigarettes, called as dual users

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Third, the amount of behavioral support (including instruction in proper use of the product) may affect the effectiveness of e-cigarettes, but existing trials have offered low levels of behavioral support, which might have increased cessation rates of both e-cigarettes and other methods tested (Malas et al., 2016)