In particular, it is reported that cEDS patients may show delayed motor development with mild hypotonia, characteristic facial features, fatigue and muscle cramps, premature rupture of fetal membranes, cervical insufficiency during pregnancy, rectal prolapse in early childhood, mild scoliosis, and cardiac/blood vessel fragility including mitral/tricuspid valve prolapse, and aortic root dilatation
95% CI, 1.06-1.67), emphysema (IRR = 1.69
Since the 20th century, almost all cigars are made of three distinct components: the filler, the binder leaf which holds the filler together, and a wrapper leaf, which is often the highest quality leaf used
The burning of tobacco generates tar, carbon monoxide, and other dangerous substances