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The standard titration schedule starts at 2.5 mg per week for 4 weeks, then increases to 5 mg per week for another 4 weeks, with subsequent increases of 2.5 mg every 4 weeks up to a maximum of 15 mg per week (Mounjaro prescribing information, Eli Lilly)

It is a useful reminder that stimulating endogenous GH is not automatically equivalent to, or stronger than, giving GH directly and that the peptides documented effect sizes are modest even in the population where it was best studied

CBO expects the costs (which would be in Part D) to continue to outweigh the savings (which would mostly be in Part A and some in Part B) into a second decade through 2044, though the gap between the two will decrease

If starting Rybelsus in patients taking warfarin, more frequent INR monitoring is advised