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This highlights that different aspects of smoking may have distinct and even opposing effects on blood pressure, and a nuanced investigation that considers both smoking status and volume is warranted

The association between cigarette smoking and development of lung adenocarcinoma increased gradually, and exposure to cigarette smoke not only promotes cancer cell progression and stemness but also reduces the sensitivity of NSCLC cells to EGFR TKI through several potential mechanisms, including EGFR hyperactivation, c-MET overexpression, and ABCG2-depednent drug efflux [9,10,11,12]

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And secundo , its extremely gradual