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When specific cells are capable of recognising GLP-1 through the use of GLP1R, the technical term is to say that they express GLP1R The net result is that the pancreas begins to secrete insulin after receiving GLP-1, thus ensuring that insulin release occurs shortly after a meal, which is required for normal healthy functioning

A numerical increase in thyroid C-cell carcinomas was observed in rats at 400 mcg/kg/day, resulting in systemic exposures that are 56-times the human exposure achieved at 20 mcg/day based on plasma AUC