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The amount of nicotine in oral pouches, like ZYN, is similar to smokeless tobacco products, such as snus and snuff which are placed in the lip to be absorbed through the gums

In September 2021, Pfizer voluntarily pulled branded Chantix from the market due to contamination with nitrosamines, a carcinogen that has tainted the production of numerous medications in recent years, including ranitidine, nizatidine, and metformin

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