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In several studies, clinical pregnancy rates 37,38,53,54,57 , numbers of oocytes 37,59,60 , maturation rates 37,60 , fertilisation rates 38,60 , embryonic morphology and development 38,57 , implantation rates 57 , and miscarriage rates 37 were similar between smoking and non-smoking patients undergoing MAR treatment

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The results consistently indicated that smokers achieved a lower plasma concentration of the drug compared to non-smokers at the same dose, or a lower concentration/dose (C/D) ratio in smokers [28, 43, 61, 70]