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In contrast, overexpression of mitochondrial superoxide dismutase (SOD2), which increases intramitochondrial H 2 O 2 levels, enhanced HIF-1 stabilization and HIF-1 activation following nicotine treatment (Guo et al
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Table 3 Summary of outcomes, statistical results, effect sizes, and direction of effects for NRT interventions across included studies DISCUSSION This systematic review assessed the effectiveness of NRT intervention on OST cessation and reduction rate
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