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Using multiple linear regression models with combined cotinine and nicotine concentrations in the FF, R 2 values were 0.02 for the number of oocytes per OPU ( p = 0.39), 0.01 for the maturation rate ( p = 0.63), and 0.01 for the fertilisation rate ( p = 0.88)

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In contrast, under acute explosive stress conditions, such as sepsis or severe smoke damage, dysregulated mitophagy or a mismatch between mitochondrial clearance and renewal may contribute to epithelial vulnerability and cell loss, particularly when bioenergetic reserve is limited

8.1 Pharmacological interventions targeting mitochondria Mitochondrial dysfunction plays a significant role in various inflammatory lung diseases, including asthma, COPD, and pulmonary fibrosis