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doi: Online Supplemental Material: Read Online Supplemental Material (142KB) Introduction Chronic obstructive pulmonary disease (COPD) is a chronic, progressive respiratory disease most commonly caused by cigarette smoking and is a leading cause of morbidity in the United States

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Notes et rfrences [modifier | modifier le code] Doll R, Peto R, Boreham J, Sutherland I., Mortality in relation to smoking: 50 years' observation on male British doctors , BMJ , vol