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Common side effects include gastrointestinal symptoms

Many authors have suggested that the melanomas, which develop from an existing or pre-existing pigmented lesion usually undergo molecular changes (like melanocytic hyperplasia) induced by chemicals, stress, etc., or can be spontaneous or iatrogenic, before taking the form of an aggressive melanoma.[4] Although melanotic macules and melanocytic hyperplasia are clinically benign lesions, few reported cases suggest potential malignant transformation, underscoring the importance of careful clinical and histological evaluation.[5] The primary care physicians will be amongst the first to encounter patients with oral-pigmented macules

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