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The samples ranged from 1 to 28 participants (n total = 31), where the youngest age (16 years) was observed in the survey by Williams et al., and the highest mean age, in the survey by Miyagawa et al., where the intervention group had a mean age of 42.17 17 years

It inhibits tyrosine activity which reduces the production of eumelanin and promotes the pheomelanin production