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It is currently approved for the treatment of Friedreichs ataxia, a genetic disorder characterized by mitochondrial impairment (Pilotto et al., 2024

Still, we discovered weak GSH-dependent reductase activity with GAPDH-SG

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Since the discovery of FSP1, more and more GPX4-independent ferroptosis pathways have been discovered in various physiological and pathological processes Drugs targeting GPX4-independent ferroptosis pathway may become a new direction for the treatment of diseases