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It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis

Genetic and epigenetic studies Organoids are amenable to genetic editing tools like CRISPR/Cas9, enabling detailed investigations into gene functions, disease mechanisms and epigenetic impacts

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These smaller molecules can independently suppress appetite and are associated with lower body weight and improved glucose regulation