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Recent animal study suggests that TCF7L2 regulates the stimulatory actions of nicotine on a habenulapancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions 46

Human evidence Although human evidence remains limited due to the relatively recent rise in e-cigarette use, epidemiologic studies are beginning to corroborate preclinical findings

9 Quitting statistics and benefits Quitting vaping and smoking in Michigan The CDC estimates 51.2% of daily adult smokers in Michigan quit smoking for one or more days in 2019.3 In 2014, the Affordable Care Act required that Medicaid programs cover all tobacco cessation medications.7** Michigans state quit line invests 58 cents per smoker, compared to the national average of $2.28.7 Michigan does not have a private insurance mandate provision for cessation.7 Notes and references Updated August 2021 *National and state-level prevalence numbers reflect the most recent data available

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