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Nicotine addiction is associated with several life-threatening physical and physiological disorders, such as cancer, heart attack, respiratory diseases, depression, obsessive-compulsive disorder, panic attacks, schizophrenia, dementia, and many more

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In 2004, the International Agency for Research on Cancer (IARC) judged that there was sufficient evidence in humans that tobacco smoking causes cancers of the lung, larynx, oral cavity and pharynx, paranasal sinuses, oesophagus, stomach, pancreas, liver, kidney, ureter, bladder, uterine cervix and bone marrow (myeloid leukaemia