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Side Effects of Misuse and Overuse Smoking leads to disease and disability and harms nearly every organ of the body

A 2022 study by University of Bristol researchers found that, based on the current balance of evidence, using triangulated data from recent population-level cross-contextual comparisons, individual-level genetic analyses and modeling, we do believe, however, that causal claims about a strong gateway effect from e-cigarettes to smoking are unlikely to hold while it remains too early to preclude other smaller or opposing effects. A 2020 study by Colin Mendelsohn and Wayne Hall concluded that claims of vaping serving as a gateway to smoking are unconvincing

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A recent study in the BMJ also suggested Juul is being used by smokers in addition to cigarettes, rather than as a replacement