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Topical immunomodulators such as tacrolimus and pimecrolimus are not as fast-acting or effective as ultrapotent topical corticosteroids in the treatment of this skin condition, although they can be considered in the maintenance phase of treatment

"We believe that smoke-free alternatives, including heated tobacco products like IQOS and e-cigarettes, have significant potential to be less harmful than cigarettes and can play an important role for smokers and public health." Simon Clark from the smokers' group Forest said: "Electronic cigarettes are a step too far for many smokers so if the government wants smokers to quit there has to be a range of products that fills the gap between combustible tobacco and e-cigarettes."

Local industry insiders have informed 2FIRSTS that the process of policy change in Japan is slow and time-consuming, including the steps of "proposing a bill, commissioning committee review, deliberation in the full session of the Diet, and voting (excluding publication)"

Besides not being in one, single physical location, it also seems to have no real mainstream headliners standout among their line up