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Such C-terminus optimization will be essential for S export and a robust immune response to genetic vaccines against the wide diversity of C-terminal residues in S proteins encoded by CoVs of human concern, including the lethal MERS-CoV and human CoV OC43 associated with common cold-like symptoms 43,71

The primary injury results in localized brain damage, while the secondary damage initiates inflammatory responses, followed by the disruption of the blood-brain barrier, infiltration of peripheral blood cells, brain edema, and the release of various immune mediators, including chemotactic factors and interleukins