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Joinpoint regression analysis of the disease burden of LC attributable to smoking The Joinpoint regression analysis of the ASMR and ASDR for LC attributable to smoking in China from 1990 to 2021 revealed significant gender disparities (Figure 2, and Supplementary file Table 2)

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In the final model, we included a spline on age, random slope on age by study and the bias covariate encoding exposure definition (that is, current, former and ever smokers), which was picked by the variable selection algorithm 28,29

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