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So, by silencing the circuit, we were able to demonstrate for certain that this was a very important neural encoder of the behavioral aspect of high-dose nicotine. The only drug designed to help with nicotine cessation, varenicline, could work by increasing aversion via the alpha-7 receptor and lessening desensitization of the alpha-4/beta-2 receptor, she said, but its precise mechanism of action is currently unknown

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The passage of this ordinance demonstrates the Ann Arbor City Councils commitment to the health and well-being of the community," said Michael Miller, regional chief mission officer of Saint Joseph Mercy Health System, in a statement

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