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Inflammasome activation and regulation: Toward a better understanding of complex mechanisms
As injectable products, they are classified as medicinal products requiring regulatory approval which most do not possess
VacA exerts multiple effects on epithelial cells resulting in the induction of vacuole formation in the gastric epithelial cellular membrane, cellular damage, an increase of intracellular permeability and the modulation of apoptosis rather than release of pro-inflammatory cytokines (see Fig
The results further support that a maternal environment of increased OS and decreased antioxidants renders both the mother and fetus more susceptible to ROS-induced damage
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