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Graphical Abstract Similar content being viewed by others Introduction Electronic nicotine delivery systems (ENDS), commonly known as electronic (e-) cigarettes or vapes, are battery-powered devices that deliver aerosol, containing nicotine and other constituents such as propylene glycol, vegetable glycerin, and flavorings, classified by regulatory agencies as tobacco products [1]

Commentary: The days of smoking cigarettes are numbered in Singapore

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In addition, the study cohort consisted of middle-aged European participants, so our findings may not be generalized to other age groups and ethnic populations