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In studies examining blood GSH in AD, 7 studies used the Hachiniski Ischaemic Score (HIS 4) to differentiate those with AD from those with potential vascular causes [41, 46, 55, 58, 60, 61, 69], and 5 of those studies further used neuroimaging to support diagnosis [55, 58, 60, 61, 69] (Table 2)

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Aging, poor diet, chronic illness, stress, sleep deprivation, and exposure to toxins can all contribute to low glutathione over time

Additionally, knockdown of ATF4 expression in Np63-stably expressed NCI-H520 cells, and found that ATF4 knockdown did not alter Np63-mediated serine elevated (Supplementary Fig