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AI is even being applied to novel drug target identification, using innovative algorithms to predict new therapeutic avenues ( FIGURE 5 6 Translational biomarkers & diagnostic platforms (blood, urine, imaging) Metabolomic signatures face significant challenges due to confounding by extrinsic factors (diet, medications including SGLT2i/GLP-1RAs, comorbidities) and the predominance of cross-sectional studies with modest sample sizes, limiting causal inference and generalizability

The prolonged opening of this pore affects the redox state of the mitochondria, impairs oxidative phosphorylation, and activates apoptosis, ultimately leading to cell death

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