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Modelling cannot produce evidence: all models require some assumption about a mortality reduction from screening or must infer benefit from a surrogate observation (eg, stage shift).48 Non-randomised evidence should be ignored as such comparisons are vulnerable to prevention bias49: people who choose to be screened are systematically healthier than those who are not screened.50 Finally, policy makers have an ethical imperative to hold screening to the highest evidence standard

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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Cravo A.S., Bush J., Sharma G., Savioz R., Martin C., Craige S., et al