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(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

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Impaired bioavailability of vitamin B6 may affect the nervous system because it is required for the synthesis of neurotransmitters including serotonin, dopamine and taurine [110]

Neurological examination revealed mild weakness in the bilateral upper and proximal lower limbs, brisk deep tendon reflexes and bilateral extensor plantar response, suggesting myelopathy