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Smoking often leads to dehydration and reduced blood flow towards the gut, this damages the mucosal lining and makes it more susceptible to ulcers and injuries

As part of its Comprehensive Plan, FDA issued guidance that pushed back premarket review application deadlines to August 2021 for newly deemed combustible tobacco products (e.g., cigars) and August 2022 for newly deemed noncombustible tobacco products (e.g., ENDS) on the market as of August 8, 2016