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Whilst some brands can contain up to 28mg of nicotine per cigarette, it is typical for between only 1.1mg and 1.8mg of nicotine per cigarette to enter the bloodstream, as a large quantity is lost in the burning process
Given those metrics, we can also know that giving up smoking is very hard, especially for people who have been doing it for most of their lives
Since there are no early stopping rules or planned interim analysis and because the medication being investigated in the study is available on pharmacy shelves, a Data Monitoring Committee was deemed unnecessary
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