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During development, ROS have been shown to alter vital pathways by regulating transcription factors such as activator protein (Ap1), hypoxia-inducible factor (HIF1), nuclear factor B (NF-B), nuclear factor (NF)-E2 related factor 1 and 2 (Nrf1, Nrf2), and redox-sensitive factors such as redox effector factor-1 (Ref-1) and wingless-related integration site (Wnt), which play crucial roles in proliferation, differentiation, and apoptosis (Ma, 2013)

They are not permitted in checked luggage

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