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To evaluate the quality of the selected RCTs, risk of bias was assessed using the revised Cochrane risk of bias tool for randomized trials (RoB 2.0) [33]

Preclinical research indicates GHK-Cu has the capacity to modulate the expression of over 4,000 human genes, according to bioinformatics analyses conducted by Pickart and colleagues, with a substantial subset of these genes tied directly to extracellular matrix maintenance, collagen production, and tissue-repair signaling

Patchy has interacted with SpongeBob in "SpongeBob's Big Birthday Blowout" where he sent his head to SpongeBob as a gift