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The e liquid is the substance heated in these devices to produce vapour, and it typically contains nicotine, flavourings, and other additives

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Biochem Biophys Res Commun 446:12041210 Wang J, Pareja KA, Kaiser CA, Sevier CS (2014b) Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

However, certain substances can control the dopamine reward pathway, causing our brain to associate consumption of the substance with pleasurable emotions by stimulating dopamine release when the drug is taken