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Starting in the 1950s and lasting at least through 2006, different tobacco companies "at different times and using different methods, have intentionally marketed to young people under the age of twenty-one in order to recruit 'replacement smokers' to ensure the economic future of the tobacco industry." 5

They have shown in the past that they are successful in challenging regulatory obstacles. Philip Morris International spent $9.8 million on lobbying Congress and agencies in 2012 on trade and other issues, according to disclosure records

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False Discovery Rate (FDR) was used to correct the p-values for multiple comparison error