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There is significant evidence that, besides inducing overexpression of the genetic expression and an increase in apoptosis inhibitory proteins (Bcl-2, Bcl-xL, XiAP), IL-8 can also inhibit proteolytic activation of caspase-3

Stroke 50 , 18051811 (2019)

It suggests that HDAC6 displays a ubiquitin binding capacity and facilitates aggresome formation, representing a protective strategy against neurological disorders

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