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The Tobacco Control Act amends the Federal Cigarette Labeling and Advertising Act (FCLAA) of 1965 to require each cigarette package and advertisement to bear one of the new required warnings

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Such issues constrain interpretations from single studies and necessitate the post hoc integration of results from multiple independently conducted studies to better estimate parameters of interest [25]

Cigarette smoking kills at least 473,000 deaths per year and exposure to second hand smoke causes more than 19,000 deaths per year totaling more than 490,000 deaths per year