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doi: 10.1016/j.hbpd.2021.04.007 165 ZhangNYaoHZhangZLiZChenXZhaoYet al

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Indeed, global GSH depletion in mice has been shown to cause rapid weight loss and death within 2 weeks, whereas liver-specific GSH depletion does not result in such systemic toxicity, despite the liver being the primary site of GSH synthesis (12)

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