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Following lytic reactivation, upregulated vIRF-1 in HHV-8-infected cells activated NIX-mediated mitophagy to inhibit apoptosis and promote productive viral replication, which plays a critical role in maintaining viral load within the host and for Kaposis sarcoma pathogenesis [128]

IFN Elevation Drives Immune Endotype of Sjgren Disease FRIDAY, July 24, 2026 -- Elevation of interferon (IFN) drives an immune endotype of Sjgren disease, according to a study published in the August issue of The Lancet