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Side effects tend to be mild: injection site reactions, some joint stiffness, occasional water retention early on
Clostridium butyricum produces the postbiotic butyrate which stimulates GLP-1. Bifidobacterium infantis produces the postbiotics acetate and lactate which feed bacteria such as Akkermansia and Butyricum, promoting an ecosystem in the gut that supports a healthy gut lining and naturally boosts GLP-1
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Although these agents can be used in CKD patients with an eGFR down to 15 mL/min/1.73 m 2 , the safety of GLP-1 receptor agonists in DKD patients with stage 5 CKD needs to be investigated
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