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it also activates the GIP (glucose-dependent insulinotropic polypeptide) receptor

FIGURE 3 Furthermore, nitric oxide (NO) serves multiple physiological functions, acting as a neurotransmitter in the nervous system, preserving vascular homeostasis, and regulating immune responses (Tuteja et al., 2004

3 Insulin resistance in type 1 diabetes Insulin resistance is associated with micro- and macrovascular complications in patients with T1D ( Supplementary Figure 1 )

Phenotypic outcomessuch as improved insulin sensitivity or enhanced thermogenesismay provide more robust translational anchors than circulating peptide levels alone