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In studies on lab mice, those exposed to e-cigarette smoke had higher levels of DNA damage in the heart, lungs, and bladder, compared with control mice exposed to filtered air, said Similar effects were seen when human lung and bladder cells were exposed to nicotine and nicotine-derived nitrosamine ketone (NNK), a carcinogenic nicotine derivative

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In the final flashback, the audience is reminded of Dana Scully's first day on the X-Files and shows the CSM listening in on the agents' first conversation