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After making her acting debut with a minor role in the thriller Hangmen (1987), Bullock received early attention for her supporting role in the action film Demolition Man (1993)

Exposure to air pollution has been associated with altered DNA methylation in humans 105 and has been studied in mouse models: C57BL/6J mice exposed to particulate air pollution exhibited lower H3K9me2/me3 repressive histone marks and displayed increased levels of tau phosphorylation, indicating particulate matter in polluted air may play a role in neurodegeneration via epigenetic mechanisms 106

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The artifice, when youre in the stadium, is in the foreground: the hurried erecting and taking down of sets, with production platoons dashing to and fro