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May 2021;15(3):676-683

De Pablo-Fernandez E, Sierra-Hidalgo F, Benito-Len J, Bermejo-Pareja F

S.Vila-ViosaD.MachuqueiroM.VictorB

Large amounts of hepatocyte necrosis during liver failure can lead to the release of HMGB1 from hepatocytes, as HMGB1 has a similar effect to endotoxin, HMGB1 is also involved in the pathogenesis of ALF (46)