Medically reviewed by FormBlends Clinical Review Updated: March 2026 Disclosure: FormBlends is one of the providers compared in this article
The certainty of evidence, assessed using GRADE methodology, ranged from high for colorectal cancer to moderate for liver cancer to low for pancreatic cancer, reflecting variations in trial consistency and event rates (Pieber et al., 2019
Beyond established pharmacological mechanisms such as improved glucose-dependent insulin secretion, delayed gastric emptying, and appetite modulation, growing evidence indicates that the intestinal microbial ecosystem may contribute to interindividual differences in treatment outcomes
PBH is a debilitating condition with no approved treatment options, and we look forward to advancing this critical work with avexitide into Phase 3 for individuals with PBH based on the totality of data from five clinical trials, and informed by our ongoing work to address endocrine and metabolic aspects of Wolfram syndrome