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The content of the manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the California Tobacco-Related Disease Research Program, the National Institutes of Health, or the California Department of Public Health

Differing observations, or opinions, could be due to the virus not infecting the plant, a symptomless response of the plant to a virus infection, or the isolation of a new variant or a mixture of viruses that might cause much more severe symptoms

What to watch Several developments could shape the next phase of this issue

38 PATHOPHYSIOLOGY OF EC-INDUCED NEUROTOXICITY Although research on the mechanisms underlying EC-induced neurotoxicity is limited, impaired integrity of the blood-brain barrier (BBB) appears to be a key factor